SLAS Technology explores ways in which scientists adapt advancements in technology for scientific exploration and experimentation, especially in life sciences research and development. This includes drug-delivery; diagnostics; biomedical and molecular imaging; personalized and precision medicine; high-throughput and other laboratory automation technologies; micro/nanotechnologies; analytical, separation and quantitative techniques; synthetic chemistry and biology; informatics (data analysis, statistics, bio, genomic and chemoinformatics); and more. The journal was published from 1996 through 2016 with the title Journal of Laboratory Automation. Its name changed in 2017 to more accurately reflect the evolution of its editorial scope.[
SLAS Technology Postings
Mar 04, 2020 | Justin Shumate, Pierre Baillargeon, Timothy P. Spicer, and Louis Scampavia
Critical to maintaining quality control in high-throughput screening is the need for constant monitoring of liquid-dispensing fidelity. Traditional methods involve operator intervention with gravimetric analysis to monitor the gross accuracy of full plate dispenses, visual verification of contents, or dedicated weigh stations on screening platforms that introduce potential bottlenecks and increase the plate-processing cycle time.</p> <p>We present a unique solution using open-source hardware, software, and 3D printing to automate dispenser accuracy determination by providing real-time dispense weight measurements via a network-connected precision balance. This system uses an Arduino microcontroller to connect a precision balance to a local network. By integrating the precision balance as an Internet of Things (IoT) device, it gains the ability to provide real-time gravimetric summaries of dispensing, generate timely alerts when problems are detected, and capture historical dispensing data for future analysis. All collected data can then be accessed via a web interface for reviewing alerts and dispensing information in real time or remotely for timely intervention of dispense errors. The development of this system also leveraged 3D printing to rapidly prototype sensor brackets, mounting solutions, and component enclosures....