I have a customer who ask close to prototyping jobs with low volume and high-mix components. A regular job have around 5-30 pieces board but have high quantity and many type of components. All the time over 1000 pieces of parts on board from 250-350 type. Nowadays we have jobs over 400 types of parts on a setup.
About pick & place machines: I have three Siplace, two S20 and one F4+WPC. S-line is cheap now but they are enought fast, if you can get S23-25-27 because they not analog, they are digital, they are way better for 0201. Anyways, 0201 can be placed with special feeders only which make a bit higher cost. F4 can handle clearly any size of parts and in WPC module you can store 20 tray. With Siplace line I have problems with stick magazines which are expensive and not easy-to-use sometimes. All of my machines have one internal tray holder that is why the transport widht are 250 mm only but I'm more flexible during the production. Maintenance cost is clearly good on Siplace if you have older machines, I do yearly one big repair (replacing hoses, filter, calibration), sometimes I have bigger issues but nothing impossible. Feeder cost is not a big deal nowadays. I can buy 2x8mm feeders around 30-50$ maximum and 12/16mm feeders became to cheaper everyday as the big manufacturer sell them for cheap - they are using Fuji, Juki or newer SiPlace machines. Same on replacement parts, cheap used parts are good for low-cost production, there are many chinese and european company who have parts for bucks only.
About paste printers: If you need flexibility and have well trained operators, I bet to Ekra printers. X4, X5 now is really cheap and E4-E5 (what we have) like a metal-garbage on sales prices. They are way flexible in use as DEK or other machines. Making a new printing software takes 10-15 mins maximum and the machine have a very good man-interface. DEK more faster, robust and accurate machine, have features better for reliable-production - like automatic stencil aligment - but its man-interface is strange and need time to learn/understand how to program it. If you have knowledge with DEK its quite fast and good machine too - way better as Ekra.
About reflow: we are using Rehm reflows but I can not recommend them if you havent time and knowledge in maintenance. Getting parts, making its works sometimes a real headache but they are robust and long-lasting ovens. I have a V6 which is like a dinosaur but it won't fall out in our production anymore. V7-V8-VX is worst but VXP+ is a work-horse again.
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